Sargiannidou Irene, Qiu Cuie, Tuszynski George P
Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Semin Thromb Hemost. 2004 Feb;30(1):127-36. doi: 10.1055/s-2004-822977.
The major route of tumor spread is through the bloodstream. Once in circulation, the tumor cells aggregate in clumps with platelets, which enhances the tumor cell survival. The tumor emboli will then adhere to the endothelium and by the release of proteases extravasation of the cells will occur. One of the platelet-secreted proteins is thrombospondin-1. In this article, thrombospondin-1 will be described as a modulator of angiogenesis through its role in regulating endothelial cell apoptosis, protease expression, and vascular endothelial growth factor expression. We hope to convey the idea that activity of thrombospondin-1 in tumor progression is dependent upon its interaction with several host- and tumor-associated proteins.
肿瘤扩散的主要途径是通过血液循环。一旦进入循环系统，肿瘤细胞就会与血小板聚集形成团块，这会提高肿瘤细胞的存活率。然后肿瘤栓子会黏附在内皮细胞上，并通过释放蛋白酶使细胞发生外渗。血小板分泌的一种蛋白质是血小板反应蛋白-1。在本文中，血小板反应蛋白-1将被描述为一种血管生成调节剂，因为它在调节内皮细胞凋亡、蛋白酶表达和血管内皮生长因子表达方面发挥作用。我们希望传达这样一个观点，即血小板反应蛋白-1在肿瘤进展中的活性取决于它与几种宿主和肿瘤相关蛋白的相互作用。
