Huang Tingting, Sun Li, Yuan Xianglin, Qiu Hong
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Oncotarget. 2017 Jul 11;8(48):84546-84558. doi: 10.18632/oncotarget.19165. eCollection 2017 Oct 13.
Thrombospondins are a family of extracellular matrix (ECM) proteins. Thrombospondin-1 (TSP1) was the first member to be identified and is a main player in tumor microenvironment. The diverse functions of TSP1 depend on the interactions between its structural domains and multiple cell surface molecules. TSP1 acts as an angiogenesis inhibitor by stimulating endothelial cell apoptosis, inhibiting endothelial cell migration and proliferation, and regulating vascular endothelial growth factor bioavailability and activity. In addition to angiogenesis modulation, TSP1 also affects tumor cell adhesion, invasion, migration, proliferation, apoptosis and tumor immunity. This review discusses the multifaceted and sometimes opposite effects of TSP1 on tumor progression depending on the molecular and cellular composition of the microenvironment. Clinical implications of TSP1-related compounds are also discussed.
血小板反应蛋白是细胞外基质（ECM）蛋白家族。血小板反应蛋白-1（TSP1）是首个被鉴定的成员，是肿瘤微环境中的主要参与者。TSP1的多种功能取决于其结构域与多种细胞表面分子之间的相互作用。TSP1通过刺激内皮细胞凋亡、抑制内皮细胞迁移和增殖以及调节血管内皮生长因子的生物利用度和活性，发挥血管生成抑制剂的作用。除了调节血管生成外，TSP1还影响肿瘤细胞的黏附、侵袭、迁移、增殖、凋亡和肿瘤免疫。本文综述讨论了TSP1根据微环境的分子和细胞组成对肿瘤进展产生的多方面且有时相反的影响。还讨论了与TSP1相关化合物的临床意义。
