通过斜入射反射率差分显微镜对生物分子微阵列进行无标记检测。
Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy.
作者信息
Landry J P, Zhu X D, Gregg J P
机构信息
Department of Physics, National Science Foundation Center for Biophotonics Science & Technology, University of California at Davis, Davis, California 95616, USA.
出版信息
Opt Lett. 2004 Mar 15;29(6):581-3. doi: 10.1364/ol.29.000581.
PMID:15035477
Abstract
We developed an oblique-incidence reflectivity difference (OI-RD) scanning microscope for label-free imaging of microarrays of biomolecules upon solid substrates. We demonstrate that hybridization reactions in an oligonucleotide microarray fabricated upon a glass slide can be detected by such an OI-RD microscope.
摘要
我们开发了一种斜入射反射率差分（OI-RD）扫描显微镜，用于对固体基质上生物分子微阵列进行无标记成像。我们证明，通过这种OI-RD显微镜可以检测在载玻片上制造的寡核苷酸微阵列中的杂交反应。
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