Saijo Ryuichiro, Majima Yuichi, Hyo Noboru, Takano Hiroshi
Department of Otorhinolaryngology, Mie University School of Medicine, Japan.
Am J Rhinol. 2004 Jan-Feb;18(1):1-7.
The topical administration of steroids or antibiotics to the nose and the sinuses is one of the important postsurgical therapies of endoscopic sinus surgery (ESS).
To investigate the effective deposition of aerosols in the paranasal sinuses after ESS, we restored the human nasosinus model that underwent ESS and studied the particle depositions on the ostiomeatal complex (OMC), maxillary, and ethmoid sinuses quantitatively.
A 45 degree nozzle insertion angle significantly increased the particle depositions more than the 30 degree angle (p < 0.05). A computer simulation-assisted analysis shows that the inertial deposition at OMC increased with a nozzle angle of 45 degrees versus 30 degrees. The particles with 5.63 microm in diameter significantly deposit on OMC and maxillary sinus compared with the particles with 16.37 microm (p < 0.05).
The topical administration of drugs to the paranasal sinuses postoperatively must be performed in consideration with aerodynamics of aerosols.
在鼻子和鼻窦局部应用类固醇或抗生素是内窥镜鼻窦手术（ESS）重要的术后治疗方法之一。
为研究ESS后气雾剂在鼻窦中的有效沉积情况，我们重建了接受ESS的人体鼻窦模型，并定量研究了在窦口鼻道复合体（OMC）、上颌窦和筛窦上的颗粒沉积情况。
45度的喷嘴插入角度比30度的角度显著增加了颗粒沉积（p < 0.05）。计算机模拟辅助分析表明，与30度相比，45度的喷嘴角度使OMC处的惯性沉积增加。与直径为16.37微米的颗粒相比，直径为5.63微米的颗粒在OMC和上颌窦上的沉积显著增加（p < 0.05）。
鼻窦术后局部给药必须考虑气雾剂的空气动力学因素。
