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癌症进展过程中的基因改变与基因表达调控。

Genetic alteration and gene expression modulation during cancer progression.

作者信息

Garnis Cathie, Buys Timon P H, Lam Wan L

机构信息

Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre; 601 West 10th Ave, Vancouver, BC, Canada V5Z 1L3.

出版信息

Mol Cancer. 2004 Mar 22;3:9. doi: 10.1186/1476-4598-3-9.

DOI:10.1186/1476-4598-3-9
PMID:15035667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC408463/
Abstract

Cancer progresses through a series of histopathological stages. Progression is thought to be driven by the accumulation of genetic alterations and consequently gene expression pattern changes. The identification of genes and pathways involved will not only enhance our understanding of the biology of this process, it will also provide new targets for early diagnosis and facilitate treatment design. Genomic approaches have proven to be effective in detecting chromosomal alterations and identifying genes disrupted in cancer. Gene expression profiling has led to the subclassification of tumors. In this article, we will describe the current technologies used in cancer gene discovery, the model systems used to validate the significance of the genes and pathways, and some of the genes and pathways implicated in the progression of preneoplastic and early stage cancer.

摘要

癌症通过一系列组织病理学阶段进展。人们认为进展是由基因改变的积累以及随之而来的基因表达模式变化驱动的。鉴定涉及的基因和通路不仅会增强我们对这一过程生物学的理解，还将为早期诊断提供新的靶点并促进治疗方案的设计。基因组学方法已被证明在检测染色体改变和鉴定癌症中被破坏的基因方面是有效的。基因表达谱分析已导致肿瘤的亚分类。在本文中，我们将描述用于癌症基因发现的当前技术、用于验证基因和通路重要性的模型系统，以及一些与癌前和早期癌症进展相关的基因和通路。

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