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源自3-(3-溴-4-甲氧基苯基)-4-氨基-5-巯基-1,2,4-三唑的一些N-桥连杂环的合成、表征及抗真菌活性

Synthesis, characterisation and antifungal activity of some N-bridged heterocycles derived from 3-(3-bromo-4-methoxyphenyl)-4-amino-5-mercapto-1,2,4-triazole.

作者信息

Holla B S, Poojary K N, Kalluraya B, Gowda P V

机构信息

Department of P.G. Studies & Research in Chemistry, Mangalore University, India.

出版信息

Farmaco. 1996 Dec;51(12):793-9.

PMID:9050212
Abstract

3-(3-Bromo-4-methoxyphenyl)-4-amino-5-mercapto-1,2,4-triazole was prepared starting from p-anisic acid. This new triazole was employed in the synthesis of some N-bridged heterocycles. All the newly synthesized compounds were characterized by analytical, IR, 1H-NMR and Mass Spectral studies. Some of the newly synthesized compounds were screened for their antifungal property against Thielaviopsis paradoxa, a fungus which is reported to cause stem-bleeding disease in coconut plants.

摘要

3-(3-溴-4-甲氧基苯基)-4-氨基-5-巯基-1,2,4-三唑由对甲氧基苯甲酸制备而成。这种新型三唑被用于合成一些氮桥杂环化合物。所有新合成的化合物均通过分析、红外光谱、¹H-核磁共振光谱和质谱研究进行了表征。对一些新合成的化合物进行了抗真菌性能筛选,测试其对奇异根串珠霉的抗菌性能,据报道该真菌会导致椰子植物发生茎流胶病。

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