一些新型含氟三取代3-硫代-1,2,4-三嗪-5-酮作为潜在抗癌剂的合成
Synthesis of some new fluorine bearing trisubstituted 3-thioxo-1,2,4-triazin-5-ones as potential anticancer agents.
作者信息
Abdel-Rahman R M
机构信息
Chemistry Department, Faculty of Education-Ain Shams University-Cairo Roxy-Egypt.
出版信息
Farmaco. 1992 Mar;47(3):319-26.
PMID:1503595
Abstract
In a search for new anticancer agents fluorine bearing trisubstituted 3-thioxo-1,2,4-triazin-5-ones (2-12) have been prepared and characterized by their elemental analysis, UV, IR and 1H-NMR spectral data. The in vitro anticancer activity of all the compounds has been determined. Compounds 3 and 7 showed a moderate activity against Leukemia/Lymphoma, Small/Non small Cell Lung, Colon carcinoma and Melanoma Cells.
摘要
为寻找新型抗癌药物，已制备了含氟的三取代3-硫代-1,2,4-三嗪-5-酮（2-12），并通过元素分析、紫外、红外和1H-核磁共振光谱数据对其进行了表征。已测定了所有化合物的体外抗癌活性。化合物3和7对白血病/淋巴瘤、小/非小细胞肺癌、结肠癌和黑色素瘤细胞显示出中等活性。
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