Brumell John H, Grinstein Sergio
Infection, Immunity, Injury and Repair Program, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5G 1X8, Canada.
Curr Opin Microbiol. 2004 Feb;7(1):78-84. doi: 10.1016/j.mib.2003.12.005.
Following invasion of host cells, Salmonella occupies an intracellular vacuole that superficially resembles a phagosome. However, unlike bona fide phagosomes that undergo a maturation process to become microbicidal phago-lysosomes, Salmonella avoid killing by arresting and diverting the maturation program of the invasion vacuole. As a result of this re-routing, the bacteria generate a protected niche where they survive and replicate.
入侵宿主细胞后，沙门氏菌占据一个表面上类似于吞噬体的细胞内液泡。然而，与经历成熟过程成为杀菌性吞噬溶酶体的真正吞噬体不同，沙门氏菌通过阻止和改变入侵液泡的成熟程序来避免被杀死。由于这种重新定向，细菌产生了一个受保护的小生境，它们在其中存活和繁殖。
