Center for Infectious Disease Research and Biosafety Laboratories, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Microbes Infect. 2010 Oct;12(11):809-18. doi: 10.1016/j.micinf.2010.05.010. Epub 2010 Jun 9.
Salmonella, a Gram-negative facultative intracellular pathogen is capable of infecting vast array of hosts. The striking ability of Salmonella to overcome every hurdle encountered in the host proves that they are true survivors. In the host, Salmonella infects various cell types and needs to survive and replicate by countering the defense mechanism of the specific cell. In this review, we will summarize the recent insights into the cell biology of Salmonella infection. Here, we will focus on the findings that deal with the specific mechanism of various cell types to control Salmonella infection. Further, the survival strategies of the pathogen in response to the host immunity will also be discussed in detail. Better understanding of the mechanisms by which Salmonella evade the host defense system and establish pathogenesis will be critical in disease management.
沙门氏菌是一种革兰氏阴性兼性细胞内病原体，能够感染大量宿主。沙门氏菌能够克服宿主遇到的每一个障碍，这一惊人的能力证明了它们是真正的幸存者。在宿主中，沙门氏菌感染各种细胞类型，并需要通过对抗特定细胞的防御机制来生存和复制。在这篇综述中，我们将总结沙门氏菌感染的细胞生物学的最新见解。在这里，我们将重点介绍涉及各种细胞类型控制沙门氏菌感染的具体机制的发现。此外，还将详细讨论病原体应对宿主免疫的生存策略。更好地理解沙门氏菌逃避宿主防御系统并建立发病机制的机制对于疾病管理至关重要。
