Kagohashi Maki, Okuma Yasuyuki, Fujishima Kenji, Kitada Tohru, Mizuno Yoshikuni
Department of Neurology, Juntendo University Izu-Nagaoka Hospital, 1129 Nagaoka, Izu-Nagaoka, Tagata, Shizuoka 410-2295, Japan.
Parkinsonism Relat Disord. 2004 Mar;10(3):169-71. doi: 10.1016/j.parkreldis.2003.12.002.
Although blepharospasm has been occasionally associated with parkinsonism, it has rarely been reported in patients with multiple system atrophy (MSA). We report a 65-year-old woman with MSA who developed blepharospasm seven years after onset, rendering her functionally blind. Clinical course and the findings of magnetic resonance imaging indicated cerebellar type MSA. The blink reflex studies showed prolonged R2 response and enhanced recovery cycle, indicating an increased excitability of the brainstem interneurons. These results suggest that pathophysiology of blepharospasm in MSA is similar to that of essential blepharospasm. Recognition of blepharospasm in MSA patients is important, as blepharospasm is a treatable feature in this otherwise intractable disorder.
尽管睑痉挛偶尔与帕金森病相关，但在多系统萎缩（MSA）患者中很少有报道。我们报告一例65岁的MSA女性患者，发病7年后出现睑痉挛，导致其功能性失明。临床病程及磁共振成像结果显示为小脑型MSA。眨眼反射研究显示R2反应延长和恢复周期增强，表明脑干中间神经元兴奋性增加。这些结果提示，MSA中睑痉挛的病理生理学与原发性睑痉挛相似。认识MSA患者中的睑痉挛很重要，因为在这种原本难以治疗的疾病中，睑痉挛是一个可治疗的特征。
