帕金森病患者服用喹硫平后出现的刻板行为或刻板动作

Stereotyped behaviors or punding after quetiapine administration in Parkinson's disease.

作者信息

Miwa Hideto, Morita Shuhei, Nakanishi Ichiro, Kondo Tomoyoshi

机构信息

Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-8510, Japan.

出版信息

Parkinsonism Relat Disord. 2004 Mar;10(3):177-80. doi: 10.1016/j.parkreldis.2003.08.002.

DOI:10.1016/j.parkreldis.2003.08.002

PMID:15036174

Abstract

Quetiapine has been suggested to be useful for the treatment of psychosis in patients with Parkinson's disease without prominent deterioration of motor functions. We present two patients with Parkinson's disease in whom administration of quetiapine for drug-induced psychosis caused characteristic stereotyped behaviors or punding. Since stereotyped behaviors are usually associated with excessive dopaminergic activity, it is clinically important to note that stereotyped behaviors or punding may be induced by an atypical antipsychotic drug for the treatment of psychosis in patients with Parkinson's disease.

摘要

已有研究表明，喹硫平可用于治疗帕金森病患者的精神病，且不会显著恶化运动功能。我们报告了两名帕金森病患者，他们因药物性精神病服用喹硫平后出现了特征性的刻板行为或目的性动作。由于刻板行为通常与多巴胺能活动过度有关，因此临床上需要注意，在帕金森病患者中，使用非典型抗精神病药物治疗精神病时可能会诱发刻板行为或目的性动作。