Miwa Hideto, Kondo Tomoyoshi
Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama, Japan 641-8510.
Parkinsonism Relat Disord. 2005 Aug;11(5):323-5. doi: 10.1016/j.parkreldis.2005.02.009.
We report a 32-year-old male patient with early-onset Parkinson's disease who exhibited abnormally increased writing activity. The patient displayed a disabling and pronounced increased writing activity, filling up to 10 pages or more per day in a notebook, and spending more than 12 h writing. In general, there was not much meaning in most of the writing, though there was a particular preference in tabulating the names of various sport and TV personalities. The writing activity gradually diminished following treatment with quetiapine hydrochloride, an anti-psychotic agent, at 25 mg/day. Although the pathophysiological mechanism underlying the increased writing is unclear, we believe it should be regarded as a form of punding or stereotyped behavior that has been suggested to be associated with dopaminergic therapy in Parkinson's disease.
我们报告了一名32岁早发性帕金森病男性患者,其书写活动异常增加。该患者表现出致残性且明显增加的书写活动,每天在笔记本上写满多达10页或更多,花费超过12小时书写。总体而言,大部分书写内容没什么意义,不过在罗列各种体育和电视名人的名字方面有特别偏好。在使用25毫克/天的抗精神病药物盐酸喹硫平治疗后,书写活动逐渐减少。虽然书写增加背后的病理生理机制尚不清楚,但我们认为它应被视为一种刻板行为或刻板动作,有人提出这与帕金森病的多巴胺能治疗有关。