Cecil J E, Francis J, Read N W
Centre for Human Nutrition, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, UK.
Appetite. 2004 Feb;42(1):99-105. doi: 10.1016/j.appet.2003.08.003.
We previously showed that oral administration of a liquid soup preload was associated with a slower rate of gastric emptying and suppressed appetite more compared with intragastric administration of the same soup [Appetite 31(1998)377]. The present study was designed to investigate whether these results could be explained by the cephalic stimulation of acid secretion induced by oral administration. Eight healthy male subjects took part in a double-blind placebo controlled study comparing the effects of omeprazole and placebo on gastric emptying, appetite ratings and subsequent food intake following the ingestion of a liquid soup. Subjects were administered with a single oral dose of 80 mg omeprazole or placebo 3 h prior to ingesting the radiolabelled soup preload (400 kcal; 425 ml) over 15 min. Ratings of hunger, desire to eat and fullness were recorded over 135 min and gastric emptying was measured by scintigraphy. Food intake was evaluated from a test meal (yoghurt drink) given 120 min after the end of the soup ingestion. Analysis of data showed that there was no significant difference between omeprazole and placebo in gastric emptying, appetite or subsequent energy intake from the test meal. The results suggest that gastric acid secretion is not responsible for the differences in gastric emptying and appetite observed between intragastrically infused and orally administered soup preloads.
我们之前的研究表明，与将同样的汤液经胃内给药相比，口服汤液预负荷与胃排空速率较慢及更能抑制食欲有关[《食欲》31(1998)377]。本研究旨在调查这些结果是否可以通过口服给药诱导的胃酸分泌的头期刺激来解释。八名健康男性受试者参与了一项双盲安慰剂对照研究，比较奥美拉唑和安慰剂对摄入汤液后胃排空、食欲评分及随后食物摄入量的影响。在摄入放射性标记的汤液预负荷（400千卡；425毫升）15分钟前，受试者单次口服80毫克奥美拉唑或安慰剂。在135分钟内记录饥饿、进食欲望和饱腹感评分，并通过闪烁扫描法测量胃排空。在汤液摄入结束120分钟后给予测试餐（酸奶饮料）来评估食物摄入量。数据分析表明，奥美拉唑和安慰剂在胃排空、食欲或随后测试餐的能量摄入方面没有显著差异。结果表明，胃酸分泌并非胃内输注和口服汤液预负荷之间观察到的胃排空和食欲差异的原因。
