Jones K L, Horowitz M, Carney B I, Sun W M, Chatterton B E
Department of Medicine, Royal Adelaide Hospital, Australia.
Gut. 1996 Mar;38(3):310-5. doi: 10.1136/gut.38.3.310.
To evaluate the effects of cisapride on gastric emptying of extracellular fat and hunger and fullness 10 volunteers consumed a meal consisting of 60 ml technectium-99m (99mTc)-V-thiocyanate labelled olive oil and 290 ml indium-113m (113mIn) labelled soup after taking cisapride (10 mg four times daily orally) and placebo, each for four days, in randomised, double blind fashion. Gastric emptying was quantified scintigraphically. Hunger and fullness before and after the meal were evaluated using visual analogue scales. Cisapride accelerated gastric emptying of oil and aqueous components by reducing the lag phase mean (SEM) (20.3 (7.0) min v 40.7 (4.1) min (p < 0.05) for oil and 4.1 (2.5) min v 10.0 (3.1) min (p < 0.05) for aqueous). Cisapride had no effect on the post-lag emptying rate of oil. Treatment with cisapride was associated with reduced retention of oil in the proximal stomach (p < 0.05). Subjects were more hungry before ingestion of the meal while receiving cisapride (6.7 (0.9) v 3.9 (0.7), p < 0.001). The scores for hunger at 120 and 180 minutes were inversely related to gastric emptying of oil on both cisapride (r > -0.62, p < 0.05) and placebo (r > -0.86, p < 0.001). Fullness increased after the meal while receiving placebo (p < 0.01), but not cisapride and postprandial fullness was less with cisapride at (30 min; 0.4 (0.3) v 3.3 (1.0), p < 0.05). With placebo, but not cisapride, the score for fullness at 15 minutes was inversely related to emptying of the aqueous phase (r = 0.68, p < 0.05). These results show that in normal volunteers after ingestion of an oil/aqueous meal: (a) postprandial hunger is inversely related to gastric emptying of oil, while fullness is inversely related to gastric emptying of the aqueous phase, (b) cisapride affects the intragastric distribution and accelerates gastric emptying of both oil and aqueous meal components, and (c) cisapride increases preprandial hunger and reduces postprandial fullness.
为评估西沙必利对细胞外脂肪胃排空及饥饿和饱腹感的影响，10名志愿者在随机、双盲的方式下，分别服用西沙必利（每日口服4次，每次10毫克）和安慰剂，各为期4天，之后食用由60毫升锝-99m（99mTc）-V-硫氰酸盐标记的橄榄油和290毫升铟-113m（113mIn）标记的汤组成的一餐。通过闪烁扫描法定量胃排空情况。使用视觉模拟量表评估进餐前后的饥饿和饱腹感。西沙必利通过缩短延迟期均值（标准误）来加速油相和水相成分的胃排空（油相：20.3（7.0）分钟对40.7（4.1）分钟（p<0.05）；水相：4.1（2.5）分钟对10.0（3.1）分钟（p<0.05））。西沙必利对油相延迟期后的排空速率无影响。西沙必利治疗与近端胃中油的潴留减少相关（p<0.05）。在服用西沙必利期间，受试者在进餐前更饥饿（6.7（0.9）对3.9（0.7），p<0.001）。在西沙必利组和安慰剂组，120分钟和180分钟时的饥饿评分均与油相胃排空呈负相关（西沙必利组r>-0.62，p<0.05；安慰剂组r>-0.86，p<0.001）。服用安慰剂后进餐后饱腹感增加（p<0.01），但服用西沙必利后无此现象，且西沙必利组餐后饱腹感在30分钟时较低（0.4（0.3）对3.3（1.0），p<0.05）。在安慰剂组，而非西沙必利组，15分钟时的饱腹感评分与水相排空呈负相关（r=0.68，p<0.05）。这些结果表明，在正常志愿者摄入油/水混合餐后：（a）餐后饥饿与油相胃排空呈负相关，而饱腹感与水相胃排空呈负相关；（b）西沙必利影响胃内分布并加速油相和水相餐食成分的胃排空；（c）西沙必利增加餐前饥饿感并降低餐后饱腹感。
