化学酶促动态动力学拆分
Chemoenzymatic dynamic kinetic resolution.
作者信息
Pàmies Oscar, Bäckvall Jan-E
机构信息
Department of Physical and Inorganic Chemistry, Rovira i Virgili University, Pl. Imperial Tarraco 1, 43005 Tarragona, Spain.
出版信息
Trends Biotechnol. 2004 Mar;22(3):130-5. doi: 10.1016/j.tibtech.2004.01.005.
Abstract
During the past decade a new concept has appeared in asymmetric catalysis involving the combination of a biocatalyst and a chemocatalyst in one 'pot' leading to efficient deracemization via dynamic kinetic resolution (DKR). Here, we outline the different strategies that have been developed for efficient chemoenzymatic DKR, in particular the powerful combination of an enzyme and a metal catalyst.
摘要
在过去十年中，不对称催化领域出现了一个新概念，即将生物催化剂和化学催化剂在一个“反应釜”中结合，通过动态动力学拆分（DKR）实现高效的消旋化。在此，我们概述了为实现高效化学酶法DKR而开发的不同策略，特别是酶与金属催化剂的强大组合。
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