Krumlinde Patrik, Bogár Krisztián, Bäckvall Jan-E
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
J Org Chem. 2009 Oct 2;74(19):7407-10. doi: 10.1021/jo9014276.
Chemoenzymatic dynamic kinetic resolution (DKR) via combined ruthenium and enzyme catalysis was used in the key step of a synthesis of a neonicotinoid pesticide derivative (S)-3. The DKR was carried out under mild conditions with low catalyst loading. The method gives (S)-3 in high enantiomeric excess (98%).
通过钌和酶催化相结合的化学酶促动态动力学拆分（DKR）用于新烟碱类农药衍生物（S）-3合成的关键步骤。该DKR在温和条件下以低催化剂负载量进行。该方法以高对映体过量（98%）得到（S）-3。
