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An ex vivo study exploring the diagnostic potential of 1H magnetic resonance spectroscopy in squamous cell carcinoma of the head and neck region.一项探索1H磁共振波谱在头颈部鳞状细胞癌中诊断潜力的体外研究。
Head Neck. 2002 Aug;24(8):766-72. doi: 10.1002/hed.10125.
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Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with technetium-99m methoxyisobutylisonitrile single photon emission computed tomography and computed tomography: comparison with 18-fluoro-2-deoxyglucose positron emission tomography.用锝-99m甲氧基异丁基异腈单光子发射计算机断层扫描和计算机断层扫描检测放疗后复发性或持续性鼻咽癌：与18-氟-2-脱氧葡萄糖正电子发射断层扫描的比较
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Sensitivity-encoded spectroscopic imaging.
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Human breast lesions: characterization with contrast-enhanced in vivo proton MR spectroscopy--initial results.人体乳腺病变：利用对比增强磁共振氢谱进行体内表征——初步结果
Radiology. 2001 Jul;220(1):40-6. doi: 10.1148/radiology.220.1.r01jl0240.
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The choline/creatine ratio in five benign neoplasms: comparison with squamous cell carcinoma by use of in vitro MR spectroscopy.五种良性肿瘤中的胆碱/肌酸比值：通过体外磁共振波谱与鳞状细胞癌的比较。
AJNR Am J Neuroradiol. 2000 Nov-Dec;21(10):1930-5.
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In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements.人体头颈部淋巴结转移的体内1H磁共振波谱分析及其与氧分压测量结果的比较
AJNR Am J Neuroradiol. 2000 Jan;21(1):183-93.
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Feasibility study of lactate imaging of head and neck tumors.
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In vivo lactate editing with simultaneous detection of choline, creatine, NAA, and lipid singlets at 1.5 T using PRESS excitation with applications to the study of brain and head and neck tumors.在1.5T磁场下，采用PRESS激发同时检测胆碱、肌酸、N-乙酰天门冬氨酸和脂质单重态进行体内乳酸编辑，并应用于脑及头颈部肿瘤研究。
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原发性和淋巴结转移鼻咽癌的体内质子磁共振波谱分析

In vivo proton MR spectroscopy of primary and nodal nasopharyngeal carcinoma.

作者信息

King Ann D, Yeung David K W, Ahuja Anil T, Leung S F, Tse Gary M K, van Hasselt Andrew C

机构信息

Department of Diagnostic Radiology & Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China.

出版信息

AJNR Am J Neuroradiol. 2004 Mar;25(3):484-90.

PMID:15037477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8158563/
Abstract

BACKGROUND AND PURPOSE

The aim of this study was to determine the feasibility of performing in vivo proton ((1)H) MR spectroscopy of nasopharyngeal carcinoma (NPC) and to document the (1)H spectrum of this cancer.

METHODS

Twenty-seven patients with NPC lesions >1 cm(3) underwent localized (1)H MR spectroscopy performed at 1.5 T. Water-suppressed spectra from both primary tumors (nine cases) and metastatic nodes (18 cases) were obtained at TE 136 and 272. Spectra were analyzed in the time domain by using a nonlinear least squares fitting algorithm with incorporation of previous knowledge. Choline (Cho)/creatine (Cr) ratios for primary NPC and metastatic nodes were calculated and compared. Spectra from normal neck muscle of five volunteers were acquired as control data.

RESULTS

(1)H MR spectroscopy was successfully obtained in seven (78%) of nine primary tumors and 16 (89%) of 18 metastatic nodes. Intense lipid signals in the range of 0.89 to 2.02 ppm were observed in 95% of spectra at TE 136 and 91% of spectra at TE 272. At TE 136, Cho/Cr for metastatic nodes (5.3 +/- 1.6) was significantly higher than the ratio for primary (2.6 +/- 0.5) NPC lesions (P =.02). Cho/Cr ratios for NPC lesions were higher than those for normal neck muscles, for which values ranged from 0 to 0.97 and 0 to 1.1 at TE 136 and 272, respectively.

CONCLUSION

(1)H MR spectroscopy is a feasible technique for the evaluation of NPC tumors >1 cm(3). Cho/Cr ratios for the lesions were high compared with those for normal neck muscle.

摘要

背景与目的

本研究旨在确定对鼻咽癌（NPC）进行体内质子（¹H）磁共振波谱分析的可行性，并记录该癌症的¹H谱。

方法

27例病变体积>1 cm³的鼻咽癌患者接受了在1.5 T磁场下进行的局部¹H磁共振波谱分析。在TE为136和272时，获取了来自原发肿瘤（9例）和转移淋巴结（18例）的水抑制谱。通过使用结合了先验知识的非线性最小二乘拟合算法在时域中对谱进行分析。计算并比较了原发性鼻咽癌和转移淋巴结的胆碱（Cho）/肌酸（Cr）比值。采集了5名志愿者正常颈部肌肉的谱作为对照数据。

结果

在9例原发性肿瘤中的7例（78%）和18例转移淋巴结中的16例（89%）成功获得了¹H磁共振波谱。在TE为136时，95%的谱以及在TE为272时91%的谱中观察到了0.89至2.02 ppm范围内的强脂质信号。在TE为136时，转移淋巴结的Cho/Cr（5.3±1.6）显著高于原发性鼻咽癌病变（2.6±0.5）的比值（P = 0.02）。鼻咽癌病变的Cho/Cr比值高于正常颈部肌肉，在TE为136和272时，正常颈部肌肉的Cho/Cr比值分别为0至0.97和0至1.1。

结论

¹H磁共振波谱分析是评估体积>1 cm³的鼻咽癌肿瘤的一种可行技术。与正常颈部肌肉相比，病变的Cho/Cr比值较高。