McKendrick A M, Vingrys A J, Badcock D R, Heywood J T
Discoveries in Sight, Devers Eye Institute, Legacy Clinical Research and Technology Center, Portland, Oregon, USA.
Invest Ophthalmol Vis Sci. 2000 Apr;41(5):1239-47.
To characterize the visual fields of subjects with migraine headaches using static and temporal modulation perimetry.
Sixteen subjects with migraines (15 with aura, 1 without) and 15 nonheadache controls were tested. Perimetry was conducted 7 days after the offset of a headache with both static and temporally modulated targets using the Medmont M-600 automated perimeter (Medmont Pty Ltd., Camberwell, Victoria, Australia). Flicker thresholds were measured using the autoflicker test, which varies flicker rate with eccentricity. A subset of four subjects with migraines (3 with aura, 1 without) had the temporal tuning characteristics of their loss evaluated using fixed temporal frequencies (4, 6, 9, 12, and 16 Hz).
Field losses were identified with temporal modulation perimetry in 11 of 16 migraine subjects. The majority of these losses occurred in the presence of normal static thresholds (8/11). The deficits displayed temporal tuning, being greatest for higher temporal frequencies (> or =9 Hz). None of the subjects revealed deficits typical of cortical lesions. The migraine-without-aura subject displayed a selective loss to temporally modulated stimuli, which was consistent with the aura group. This defect altered over time, decreasing for 30 to 40 days but remaining, to a smaller extent, for up to 75 days after the headache event.
Visual dysfunction that is selective for temporally modulated targets occurs in migraine subjects. The migrainous pattern of dysfunction shares some features with that identified in early stages of glaucoma and raises the possibility for a common precortical vascular involvement in these two conditions.
使用静态和时间调制视野计对偏头痛患者的视野进行特征描述。
对16名偏头痛患者（15名有先兆，1名无先兆）和15名非头痛对照者进行测试。在头痛缓解7天后，使用Medmont M - 600自动视野计（澳大利亚维多利亚州坎伯韦尔市Medmont私人有限公司），对静态和时间调制目标进行视野检查。使用自动闪烁测试测量闪烁阈值，该测试随离心率改变闪烁频率。对4名偏头痛患者（3名有先兆，1名无先兆）的子集，使用固定时间频率（4、6、9、12和16赫兹）评估其视野缺损的时间调谐特性。
16名偏头痛患者中有11名通过时间调制视野计检测到视野缺损。这些缺损大多数出现在静态阈值正常的情况下（8/11）。这些缺损表现出时间调谐，在较高时间频率（≥9赫兹）时最为明显。所有受试者均未显示出典型的皮质病变缺损。无先兆偏头痛患者对时间调制刺激表现出选择性缺损，这与有先兆组一致。这种缺陷随时间变化，在头痛事件后30至40天减少，但在较小程度上持续长达75天。
偏头痛患者存在对时间调制目标有选择性的视觉功能障碍。这种功能障碍的偏头痛模式与青光眼早期发现的模式有一些共同特征，并增加了这两种情况在皮质前血管共同受累的可能性。
