Loring David W, Meador Kimford J
Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.
Neurology. 2004 Mar 23;62(6):872-7. doi: 10.1212/01.wnl.0000115653.82763.07.
Cognitive impairment associated with antiepileptic drug (AED) therapy in children is an important concern given the potential negative effects of treatment on school learning and performance. Unfortunately, there have been few studies examining the cognitive effects of AEDs in this population and no adequate studies of newer AEDs. This article will discuss the effects of the traditional and newer AEDs on neuropsychological function in children. Because of various limitations in the designs of these studies, however, many of the studies report inconclusive findings. Although it will be necessary to overcome many programmatic and procedural hurdles, well-designed randomized prospective studies that are of adequate length to determine how AEDs ultimately relate to school performance and social adjustment are needed to firmly establish the cognitive and behavioral effects of AEDs in children.
考虑到抗癫痫药物（AED）治疗对儿童学校学习和表现可能产生的负面影响，与AED治疗相关的认知障碍是一个重要问题。不幸的是，很少有研究考察AEDs对该人群的认知影响，也没有对新型AEDs进行充分研究。本文将讨论传统和新型AEDs对儿童神经心理功能的影响。然而，由于这些研究设计存在各种局限性，许多研究报告的结果尚无定论。尽管有必要克服许多规划和程序上的障碍，但仍需要设计良好、时长足够以确定AEDs最终如何与学业成绩和社会适应相关的随机前瞻性研究，来确切证实AEDs对儿童认知和行为的影响。
