Ortinski Pavel, Meador Kimford J
Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20007, USA.
Epilepsy Behav. 2004 Feb;5 Suppl 1:S60-5. doi: 10.1016/j.yebeh.2003.11.008.
Antiepileptic drugs produce global changes in the excitation levels in the central nervous system and often lead to cognitive and behavioral deficits. These deficits vary and must be considered independently in every patient. A number of consistent risk factors have been established. Polypharmacy and high blood levels of an antiepileptic drug (AED) increase the risk of cognitive side effects. Different effects have been demonstrated for some AEDs, but comparative data are incomplete across all of them. Other factors such as patient age and type/frequency of seizures may also be important contributors to the patient's cognitive state. AEDs can have positive or negative effects on mood, providing another consideration in choosing the course of treatment.
抗癫痫药物会引起中枢神经系统兴奋水平的整体变化，且常导致认知和行为缺陷。这些缺陷因人而异，必须针对每位患者单独考虑。已确定了一些一致的风险因素。联合用药和抗癫痫药物（AED）的高血药浓度会增加认知副作用的风险。某些AED已显示出不同的作用，但所有AED的比较数据并不完整。其他因素，如患者年龄和癫痫发作类型/频率，也可能是影响患者认知状态的重要因素。AED对情绪可能有正面或负面影响，这是选择治疗方案时的另一个考虑因素。
