Hebebrand J, Geller F, Dempfle A, Heinzel-Gutenbrunner M, Raab M, Gerber G, Wermter A-K, Horro F F, Blundell J, Schäfer H, Remschmidt H, Herpertz S, Hinney A
Department of Child and Adolescent Psychiatry of the Philipps-University of Marburg, Germany.
Mol Psychiatry. 2004 Aug;9(8):796-800. doi: 10.1038/sj.mp.4001491.
Recently, Branson and coworkers reported a strong association between binge-eating disorder (BED) and variants in the melanocortin-4 receptor gene (MC4R). In the current study, we compared the eating behavior of 43 obese probands with functionally relevant MC4R mutations and of 35 polymorphism carriers (V103I or I251L) with wild-type carriers. The module for eating disorders of the Composite International Diagnostic Interview was used to identify binge-eating behavior. The Three-Factor Eating Questionnaire and the Leeds Food Frequency Questionnaire were used to assess restrained eating, disinhibition, hunger and percent total energy intake as fat. No significant differences between carriers of MC4R variants and wild-type carriers were detected. In particular, we found no evidence for an increased rate of binge-eating behavior in obese carriers of MC4R variants. Our findings do not support the strong association between BED and MC4R carrier status.
最近，布兰森及其同事报告称，暴饮暴食症（BED）与黑皮质素-4受体基因（MC4R）的变异之间存在密切关联。在本研究中，我们比较了43名具有功能相关MC4R突变的肥胖先证者以及35名多态性携带者（V103I或I251L）与野生型携带者的饮食行为。采用综合国际诊断访谈中的饮食失调模块来识别暴饮暴食行为。使用三因素饮食问卷和利兹食物频率问卷来评估节制饮食、去抑制、饥饿程度以及脂肪占总能量摄入的百分比。未检测到MC4R变异携带者与野生型携带者之间存在显著差异。特别是，我们没有发现证据表明MC4R变异的肥胖携带者中暴饮暴食行为的发生率增加。我们的研究结果不支持BED与MC4R携带者状态之间的密切关联。
