Manfredi Lucia, Accoto Alessandra, Couyoumdjian Alessandro, Conversi David
Department of Psychology, University of Rome 'La Sapienza', 00185 Rome, Italy.
Nutrients. 2021 Mar 5;13(3):848. doi: 10.3390/nu13030848.
The genetic polymorphisms involved in the physiopathology of binge eating disorder (BED) are currently unclear. This systematic review aims to highlight and summarize the research on polymorphisms that is conducted in the BED. We looked for observational studies where there was a genetic comparison between adults with BED, in some cases also with obesity or overweight, and healthy controls or obesity/overweight without BED. Our protocol was written using PRISMA. It is registered at PROSPERO (identification: CRD42020198645). To identify potentially relevant documents, the following bibliographic databases were searched without a time limit, but until September 2020: PubMed, PsycINFO, Scopus, and Web of Science. In total, 21 articles were included in the qualitative analysis of the systematic review, as they met the eligibility criteria. Within the selected studies, 41 polymorphisms of 17 genes were assessed. Overall, this systematic review provides a list of potentially useful genetic polymorphisms involved in BED: 5-HTTLPR (5-HTT), Taq1A (ANKK1/DRD2), A118G (OPRM1), C957T (DRD2), rs2283265 (DRD2), Val158Met (COMT), rs6198 (GR), Val103Ile (MC4R), Ile251Leu (MC4R), rs6265 (BNDF), and Leu72Met (GHRL). It is important to emphasize that Taq1A is the polymorphism that showed, in two different research groups, the most significant association with BED. The remaining polymorphisms need further evidence to be confirmed.
目前尚不清楚参与暴饮暴食症（BED）生理病理学的基因多态性。本系统评价旨在突出并总结针对BED所进行的基因多态性研究。我们查找了观察性研究，这些研究对患有BED的成年人（某些情况下还包括肥胖或超重者）与健康对照或无BED的肥胖/超重者进行了基因比较。我们使用PRISMA撰写了研究方案。该方案已在PROSPERO注册（识别号：CRD42020198645）。为识别潜在相关文献，我们对以下文献数据库进行了不限时间但截至2020年9月的检索：PubMed、PsycINFO、Scopus和Web of Science。共有21篇文章符合纳入标准，被纳入系统评价的定性分析。在所选研究中，评估了17个基因的41种多态性。总体而言，本系统评价提供了一份参与BED的潜在有用基因多态性列表：5-HTTLPR（5-HTT）、Taq1A（ANKK1/DRD2）、A118G（OPRM1）、C957T（DRD2）、rs2283265（DRD2）、Val158Met（COMT）、rs6198（GR）、Val103Ile（MC4R）、Ile251Leu（MC4R）、rs6265（BNDF）和Leu72Met（GHRL）。需要强调的是，Taq1A是在两个不同研究组中显示出与BED关联最为显著的多态性。其余多态性需要进一步证据加以证实。
