Bodinet Cornelia, Lindequist Ulrike, Teuscher Eberhard, Freudenstein Johannes
Schaper & Brümmer GmbH & Co. KG, Research and Development, Salzgitter, Germany.
Arzneimittelforschung. 2004;54(2):114-8. doi: 10.1055/s-0031-1296945.
The influence of the peroral administration of the macromolecular components of a herbal immunomodulator isolated from an aqueous-ethanolic extract of the mixed herbal drugs Thujae summitates, Baptisiae tinctoriae radix, Echinaceae purpureae radix and Echinaceae pallidae radix on the function of Peyer's patches cells was investigated in mice. Peyer's patches cells isolated from mice which had received oral administration of the macromolecular fraction of the plant extract developed a significantly enhanced plaque-forming cell (PFC) response to sheep red blood cells after incubation with these cells in the presence of lipopolysaccharide or the extract fraction for 7 days in vitro. These results show that after oral administration of the herbal immunomodulator, the immunologically active macromolecules can contact the cells of the gut-associated lymphoid tissue and modulate the mucosal immune response.
研究了从金缕梅、北美黄连根、紫锥菊根和淡紫锥菊根混合草药的水乙醇提取物中分离出的草药免疫调节剂的大分子成分经口给药对小鼠派伊尔结细胞功能的影响。从小鼠分离出的派伊尔结细胞，在口服植物提取物的大分子部分后，于体外在脂多糖或提取物部分存在的情况下与这些细胞孵育7天，对绵羊红细胞产生的空斑形成细胞（PFC）反应显著增强。这些结果表明，经口给予草药免疫调节剂后，具有免疫活性的大分子可与肠道相关淋巴组织的细胞接触并调节黏膜免疫反应。
