Casadevall Arturo, Pirofski Liise-anne
Departments of Medicine (Division of Infectious Diseases) and Microbiology & Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.
Nat Rev Microbiol. 2003 Oct;1(1):17-24. doi: 10.1038/nrmicro732.
The late twentieth century witnessed the emergence of numerous infectious diseases that are caused by microorganisms that rarely cause disease in normal, healthy immunocompetent hosts. The emergence of these diseases shows that the existing concepts of pathogenicity and virulence do not take into account the fact that both the microorganism and the host contribute to microbial pathogenesis. To address this impediment to studies of host-microorganism interactions, we propose a new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework.
二十世纪后期出现了许多由微生物引起的传染病，这些微生物在正常、健康且具有免疫能力的宿主中很少引发疾病。这些疾病的出现表明，现有的致病性和毒力概念没有考虑到微生物和宿主都对微生物发病机制有影响这一事实。为了解决宿主与微生物相互作用研究中的这一障碍，我们提出了一种理解微生物发病机制的新理论方法，即“损伤-反应”框架。
