Shattock Robin J, Moore John P
Department of Cellular and Molecular Medicine, Infectious Diseases, St. George's Hospital Medical School, London, UK.
Nat Rev Microbiol. 2003 Oct;1(1):25-34. doi: 10.1038/nrmicro729.
The worldwide infection rate for HIV-1 is estimated to be 14,000 per day, but only now, more than 20 years into the epidemic, are the immediate events between exposure to infectious virus and the establishment of infection becoming clear. Defining the mechanisms of HIV-1 transmission, the target cells involved and how the virus attaches to and fuses with these cells, could reveal ways to block the sexual spread of the virus. In this review, we will discuss how our increasing knowledge of the ways in which HIV-1 is transmitted is shaping the development of new, more sophisticated intervention strategies based on the application of vaginal or rectal microbicides.
据估计，全球每天的HIV-1感染率为14000例，但直到现在，在该流行病爆发20多年后，从接触传染性病毒到感染确立之间的直接事件才逐渐明晰。明确HIV-1的传播机制、涉及的靶细胞以及病毒如何附着并与这些细胞融合，可能会揭示出阻断该病毒性传播的方法。在这篇综述中，我们将讨论，随着我们对HIV-1传播方式的了解不断增加，基于阴道或直肠杀菌剂的应用，新的、更复杂的干预策略是如何发展形成的。
