[荧光标记的甘油三酯的合成及性质，抗肿瘤药物溶肉瘤素的衍生物]

[Synthesis and properties of fluorescently-labelled triglyceride, derivative of the antineoplastic agent sarcolysin].

作者信息

Boldyrev I A, Grechishnikova I V, Pavlova Iu B, Molotkovskiĭ Iu G

机构信息

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP Moscow, 117997 Russia.

出版信息

Bioorg Khim. 2004 Jan-Feb;30(1):80-3. doi: 10.1023/b:rubi.0000015776.60923.96.

DOI:10.1023/b:rubi.0000015776.60923.96

PMID:15040307

Abstract

A new fluorescent probe, a 3-perylenoyl derivative of the lipophilized antitumor drug merphalan (sarcolysine), was synthesized. The probe is suitable for studying intracellular traffic and metabolism of merphalan and its derivatives. The perylenoyl fluorescence is partially quenched by the merphalan chromophore, which broadens the probe potentialities. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.

摘要

合成了一种新型荧光探针，即亲脂性抗肿瘤药物美法仑（溶肉瘤素）的3-苝甲酰基衍生物。该探针适用于研究美法仑及其衍生物的细胞内运输和代谢。苝甲酰基荧光被美法仑发色团部分淬灭，这拓宽了探针的应用潜力。论文英文版：《俄罗斯生物有机化学杂志》，2004年，第30卷，第1期；另见http://www.maik.ru。