Nikolich-Zugich Janko, Slifka Mark K, Messaoudi Ilhem
Vaccine and Gene Therapy Institute, Department of Molecular Microbiology and Immunology and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA.
Nat Rev Immunol. 2004 Feb;4(2):123-32. doi: 10.1038/nri1292.
In the thymus, a diverse and polymorphic T-cell repertoire is generated by random recombination of discrete T-cell receptor (TCR)-alphabeta gene segments. This repertoire is then shaped by intrathymic selection events to generate a peripheral T-cell pool of self-MHC restricted, non-autoaggressive T cells. It has long been postulated that some optimal level of TCR diversity allows efficient protection against pathogens. This article focuses on several recent advances that address the required diversity for the generation of an optimal immune response.
在胸腺中，通过离散的T细胞受体（TCR）αβ基因片段的随机重组产生多样且多态的T细胞库。然后，该T细胞库通过胸腺内选择事件进行塑造，以产生一个自我MHC限制、无自身攻击性的外周T细胞库。长期以来一直有人推测，TCR多样性的某种最佳水平可实现对病原体的有效保护。本文重点介绍了近期在确定产生最佳免疫反应所需多样性方面取得的一些进展。
