Downing Sean R, Hennessy Kristen T, Abe Miyako, Manola Judith, George Daniel J, Kantoff Philip W
Lank Center for Genitourinary Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Clin Prostate Cancer. 2003 Dec;2(3):177-80. doi: 10.3816/cgc.2003.n.027.
Several genetic loci are suspected to be involved in hereditary prostate cancer, including the hereditary prostate cancer 1 (HPC1) locus at chromosome 1q24-25. The ribonuclease L (RNase L) gene has been reported as the putative hereditary prostate cancer gene located at HPC1. If this is the case, mutations of RNase L should be found at a greater frequency in familial cancers than in sporadic prostate cancers. Examination of familial and sporadic cases of prostate cancer by polymerase chain reaction and DNA sequencing resulted in a mutational frequency rate that was not statistically different between the 2 forms of the disease. These results suggest that the mutations examined within this study are rare and may contribute to very few familial prostate cancers.
有几个基因位点被怀疑与遗传性前列腺癌有关，包括位于1号染色体1q24 - 25的遗传性前列腺癌1（HPC1）位点。核糖核酸酶L（RNase L）基因被报道为位于HPC1的假定遗传性前列腺癌基因。如果是这样的话，在家族性癌症中发现核糖核酸酶L突变的频率应该高于散发性前列腺癌。通过聚合酶链反应和DNA测序对前列腺癌家族性和散发性病例进行检测，结果显示两种疾病形式的突变频率在统计学上没有差异。这些结果表明，本研究中检测到的突变很罕见，可能仅导致极少数家族性前列腺癌。
