Cortesini R
Columbia University Department of Pathology, New York, NY 10032, USA.
Transplant Proc. 2004 Mar;36(2 Suppl):158S-162S. doi: 10.1016/j.transproceed.2003.12.043.
The introduction of cyclosporine in clinical practice led to a dramatic increase in long-term graft survival. At the Transplantation Center of the University of Rome La Sapienza, the survival rate at 5, 10, and 20 years was 35%, 22%, and 20% in the precyclosporine era and 75%, 60%, and 45%, respectively, after the use of cyclosporine-based immunosuppressive therapy. However, because of the nephrotoxicity of this, drug efforts are being made to reduce or avoid the use of calcineurin inhibitors. We advocate tailoring of immunosuppression to a minimal level on the basis of immunologic tests that permit a quantitative and qualitative evaluation of regulatory and effector cells.
环孢素引入临床实践后，长期移植物存活率显著提高。在罗马第一大学移植中心，在使用环孢素之前的时代，5年、10年和20年的存活率分别为35%、22%和20%，而在使用基于环孢素的免疫抑制治疗后，相应的存活率分别为75%、60%和45%。然而，由于这种药物具有肾毒性，人们正在努力减少或避免使用钙调神经磷酸酶抑制剂。我们主张根据能够对调节性细胞和效应细胞进行定量和定性评估的免疫学检测，将免疫抑制调整到最低水平。
