Domurado D, Guidoin R, Marois M, Martin L, Gosselin C, Awad J
J Bioeng. 1978 Apr;2(1-2):79-91.
An improved vascular graft was achieved by treating knitted Dacron prostheses with cross-linked albumin. Eight segments, each six centimeters in length, were coated and implanted in the canine thoracic aorta for periods ranging from 24 hours to six months. The results were compared with the eight untreated grafts implanted for similar periods as control experiments. Albumin coating resulted in a faster healing : cells appeared earlier and collagen development was greater. The most beneficial effect of that treatment was the reduction in embolization, as shown by the considerable decrease in kidney damage.
通过用交联白蛋白处理针织涤纶假体，制成了一种改良的血管移植物。制备了8个长度均为6厘米的节段，进行涂层处理后植入犬的胸主动脉，植入时间从24小时至6个月不等。将结果与作为对照实验同期植入的8个未处理移植物进行比较。白蛋白涂层使愈合加快：细胞出现得更早，胶原蛋白生成更多。该处理最有益的效果是栓塞减少，肾脏损伤显著减轻即表明了这一点。
