Ferrante A, Kowanko I C, Bates E J
University of Adelaide, South Australia.
Immunol Ser. 1992;57:499-521.
Although extensive investigations into the role of neutrophils and their products in tissue injury have been conducted, very little work has been carried out on the role of polypeptide cytokines in the regulation of neutrophil-mediated tissue damage. A range of cytokines are known to promote a wide variety of functions of the neutrophil, including neutrophil adhesion, surface receptor expression, ODRS production, and release of lysosomal constituents. Evidence has been presented to show that these products, either singly or in combination, cause tissue injury. At this stage, TNF alpha and TNF beta are cytokines which have been shown to regulate neutrophil tissue injury. From this work it is suggested that TNFs promote neutrophil-mediated tissue damage.
尽管已经对中性粒细胞及其产物在组织损伤中的作用进行了广泛研究，但关于多肽细胞因子在调节中性粒细胞介导的组织损伤中的作用，开展的工作却很少。已知一系列细胞因子可促进中性粒细胞的多种功能，包括中性粒细胞黏附、表面受体表达、超氧阴离子产生以及溶酶体成分的释放。已有证据表明，这些产物单独或联合作用均会导致组织损伤。现阶段，肿瘤坏死因子α和肿瘤坏死因子β是已被证明可调节中性粒细胞组织损伤的细胞因子。从这项研究来看，肿瘤坏死因子可促进中性粒细胞介导的组织损伤。
