Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, P.O. Box 30.001, 9700 RB, The Netherlands.
Acta Biomater. 2012 Apr;8(4):1422-9. doi: 10.1016/j.actbio.2011.12.004. Epub 2011 Dec 13.
The present study evaluates a new synthetic degradable barrier membrane based on poly(trimethylene carbonate) (PTMC) for use in guided bone regeneration. A collagen membrane and an expanded polytetrafluoroethylene (e-PTFE) membrane served as reference materials. In 192 male Sprague-Dawley rats, a standardized 5.0mm circular defect was created in the left mandibular angle. New bone formation was demonstrated by post mortem micro-radiography, micro-computed tomography imaging and histological analysis. Four groups (control, PTMC, collagen, e-PTFE) were evaluated at three time intervals (2, 4 and 12 weeks). In the membrane groups the defects were covered; in the control group the defects were left uncovered. Data were analysed using a multiple regression model. In contrast to uncovered mandibular defects, substantial bone healing was observed in defects covered with a barrier membrane. In the latter case, the formation of bone was progressive over 12 weeks. No statistically significant differences between the amount of new bone formed under the PTMC membranes and the amount of bone formed under the collagen and e-PTFE membranes were observed. Therefore, it can be concluded that PTMC membranes are well suited for use in guided bone regeneration.
本研究评估了一种基于聚三亚甲基碳酸酯（PTMC）的新型可降解屏障膜，用于引导骨再生。胶原膜和膨化聚四氟乙烯（e-PTFE）膜作为参考材料。在 192 只雄性 Sprague-Dawley 大鼠的左侧下颌角处制造了一个标准化的 5.0mm 圆形缺损。通过死后微射线照相、微计算机断层扫描成像和组织学分析来证明新骨形成。在三个时间间隔（2、4 和 12 周）评估了 4 个组（对照组、PTMC 组、胶原组、e-PTFE 组）。在膜组中，缺陷被覆盖；在对照组中，缺陷未被覆盖。使用多元回归模型分析数据。与未覆盖的下颌骨缺损相比，在屏障膜覆盖的缺陷中观察到大量骨愈合。在后一种情况下，骨形成在 12 周内逐渐进行。在 PTMC 膜下形成的新骨量和在胶原膜和 e-PTFE 膜下形成的骨量之间没有观察到统计学上的显著差异。因此，可以得出结论，PTMC 膜非常适合用于引导骨再生。
