• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

AMP-activated protein kinase: a master switch in glucose and lipid metabolism.

作者信息

Hardie D Grahame

机构信息

Division of Molecular Physiology, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.

出版信息

Rev Endocr Metab Disord. 2004 May;5(2):119-25. doi: 10.1023/B:REMD.0000021433.63915.bb.

DOI:10.1023/B:REMD.0000021433.63915.bb
PMID:15041787
Abstract
摘要

相似文献

1
AMP-activated protein kinase: a master switch in glucose and lipid metabolism.AMP激活的蛋白激酶：葡萄糖和脂质代谢的主开关
Rev Endocr Metab Disord. 2004 May;5(2):119-25. doi: 10.1023/B:REMD.0000021433.63915.bb.
2
AMP-activated protein kinase, super metabolic regulator.AMP激活的蛋白激酶，超级代谢调节因子。
Biochem Soc Trans. 2003 Feb;31(Pt 1):162-8. doi: 10.1042/bst0310162.
3
AMP-activated protein kinase and hepatic genes involved in glucose metabolism.AMP激活的蛋白激酶与参与葡萄糖代谢的肝脏基因
Biochem Soc Trans. 2003 Feb;31(Pt 1):220-3. doi: 10.1042/bst0310220.
4
AMP activated protein kinase 2 protection during hypertension-induced hypertrophy: a common mediator in the signaling crossroads.高血压诱导的心肌肥厚过程中AMP激活的蛋白激酶2的保护作用：信号通路交叉点的共同介质
Hypertension. 2008 Nov;52(5):813-5. doi: 10.1161/HYPERTENSIONAHA.108.121244. Epub 2008 Oct 6.
5
5'-AMP-activated protein kinase signaling in Caenorhabditis elegans.秀丽隐杆线虫中的5'-AMP激活蛋白激酶信号传导
Exp Biol Med (Maywood). 2008 Jan;233(1):12-20. doi: 10.3181/0705-MR-117.
6
AMPK: a key sensor of fuel and energy status in skeletal muscle.AMPK：骨骼肌中燃料和能量状态的关键传感器。
Physiology (Bethesda). 2006 Feb;21:48-60. doi: 10.1152/physiol.00044.2005.
7
Adenosine 5'-monophosphate-activated protein kinase and p38 mitogen-activated protein kinase participate in the stimulation of glucose uptake by dinitrophenol in adult cardiomyocytes.5'-单磷酸腺苷激活的蛋白激酶和p38丝裂原活化蛋白激酶参与二硝基苯酚对成年心肌细胞葡萄糖摄取的刺激作用。
Endocrinology. 2005 May;146(5):2285-94. doi: 10.1210/en.2004-1565. Epub 2005 Jan 27.
8
AMP-activated protein kinase signaling in metabolic regulation.代谢调节中的AMP活化蛋白激酶信号传导
J Clin Invest. 2006 Jul;116(7):1776-83. doi: 10.1172/JCI29044.
9
[AMPK].[腺苷酸活化蛋白激酶]
Nihon Rinsho. 2006 Dec 28;64 Suppl 9:282-6.
10
The AMP-activated protein kinase cascade--a unifying system for energy control.AMP激活的蛋白激酶级联反应——能量控制的统一系统。
Trends Biochem Sci. 2004 Jan;29(1):18-24. doi: 10.1016/j.tibs.2003.11.005.

引用本文的文献

1
Alteration of cardiac energetics and mitochondrial function in doxorubicin‑induced cardiotoxicity: Molecular mechanism and prospective implications (Review).阿霉素诱导的心脏毒性中心脏能量代谢和线粒体功能的改变：分子机制及潜在影响（综述）
Int J Mol Med. 2025 Nov;56(5). doi: 10.3892/ijmm.2025.5624. Epub 2025 Sep 5.
2
Impact of phytosterol supplementation on metabolic syndrome factors: a systematic review of randomized controlled trials.补充植物甾醇对代谢综合征因素的影响：随机对照试验的系统评价
Diabetol Metab Syndr. 2025 Aug 18;17(1):335. doi: 10.1186/s13098-025-01887-2.
3
Targeting negative phosphorylation to activate AMPK.

本文引用的文献

1
AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus.2-氯腺苷既激活腺苷酸活化蛋白激酶，又在大鼠海马体CA1区与腺苷竞争核苷转运体。
J Neurochem. 2004 Mar;88(5):1272-82. doi: 10.1046/j.1471-4159.2003.02253.x.
2
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.CBS结构域形成能量感应模块，其与腺苷配体的结合会因疾病突变而被破坏。
J Clin Invest. 2004 Jan;113(2):274-84. doi: 10.1172/JCI19874.
3
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.
靶向负磷酸化以激活AMPK。
Endocr Connect. 2025 Jul 17;14(7). doi: 10.1530/EC-25-0260. Print 2025 Jul 1.
4
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.多金属氧酸盐通过激活 AMPK 信号通路改善代谢相关脂肪性肝病的肝功能障碍。
Int J Nanomedicine. 2024 Oct 25;19:10839-10856. doi: 10.2147/IJN.S485084. eCollection 2024.
5
-dependent monocyte expression quantitative trait loci, cytokine production, and TB pathogenesis.依赖于单核细胞表达的数量性状基因座、细胞因子产生与结核病发病机制。
Front Immunol. 2024 Mar 7;15:1359178. doi: 10.3389/fimmu.2024.1359178. eCollection 2024.
6
Caveolin-1 deficiency alleviates palmitate-induced intracellular lipid accumulation and inflammation in pancreatic β cells.窖蛋白-1 缺乏可减轻棕榈酸诱导的胰岛β细胞内脂质堆积和炎症反应。
J Physiol Biochem. 2024 Feb;80(1):175-188. doi: 10.1007/s13105-023-00995-9. Epub 2023 Nov 30.
7
Berberine and Its Study as an Antidiabetic Compound.小檗碱及其作为抗糖尿病化合物的研究。
Biology (Basel). 2023 Jul 8;12(7):973. doi: 10.3390/biology12070973.
8
Chemical Characterization, Antilipidemic Effect and Anti-Obesity Activity of in a Murine Model of Metabolic Syndrome.在代谢综合征小鼠模型中的化学表征、抗血脂异常作用及抗肥胖活性
Plants (Basel). 2023 Jul 7;12(13):2578. doi: 10.3390/plants12132578.
9
Depletion of () leads to fatty liver disease and defective mating behavior in zebrafish.（）耗竭导致斑马鱼脂肪肝和交配行为缺陷。
Zool Res. 2023 Jan 18;44(1):63-77. doi: 10.24272/j.issn.2095-8137.2022.167.
10
Understanding Myocardial Metabolism in the Context of Cardio-Oncology.了解心血管肿瘤学背景下的心肌代谢
Heart Fail Clin. 2022 Jul;18(3):415-424. doi: 10.1016/j.hfc.2022.02.004.
LKB1是AMP激活的蛋白激酶级联反应中的上游激酶。
Curr Biol. 2003 Nov 11;13(22):2004-8. doi: 10.1016/j.cub.2003.10.031.
4
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.肿瘤抑制因子LKB1、STRADα/β和MO25α/β之间的复合物是AMP激活的蛋白激酶级联反应中的上游激酶。
J Biol. 2003;2(4):28. doi: 10.1186/1475-4924-2-28. Epub 2003 Sep 24.
5
Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes.AMP激活的蛋白激酶在3T3-L1脂肪细胞中环磷酸腺苷依赖性脂解中的作用
J Biol Chem. 2003 Oct 31;278(44):43074-80. doi: 10.1074/jbc.M308484200. Epub 2003 Aug 25.
6
Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex.Elm1p是酿酒酵母SNF1复合体的三种上游激酶之一。
Curr Biol. 2003 Aug 5;13(15):1299-305. doi: 10.1016/s0960-9822(03)00459-7.
7
AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.运动后大鼠肌肉、肝脏和脂肪组织中作为代谢开关的AMPK
Acta Physiol Scand. 2003 Aug;178(4):435-42. doi: 10.1046/j.1365-201X.2003.01164.x.
8
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.上游激酶对酵母Snf1和哺乳动物AMP激活的蛋白激酶的激活作用。
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8839-43. doi: 10.1073/pnas.1533136100. Epub 2003 Jul 7.
9
Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling.收缩诱导的大鼠心肌细胞脂肪酸转位酶/CD36转位通过AMP激活的蛋白激酶信号传导介导。
Diabetes. 2003 Jul;52(7):1627-34. doi: 10.2337/diabetes.52.7.1627.
10
Management of cellular energy by the AMP-activated protein kinase system.AMP激活的蛋白激酶系统对细胞能量的管理
FEBS Lett. 2003 Jul 3;546(1):113-20. doi: 10.1016/s0014-5793(03)00560-x.