AMPK：骨骼肌中燃料和能量状态的关键传感器。
AMPK: a key sensor of fuel and energy status in skeletal muscle.
作者信息
Hardie D Grahame, Sakamoto Kei
机构信息
Division of Molecular Physiology, University of Dundee, Dundee, Scotland.
出版信息
Physiology (Bethesda). 2006 Feb;21:48-60. doi: 10.1152/physiol.00044.2005.
PMID:16443822
Abstract
Contraction induces marked metabolic changes in muscle, and the AMP-activated protein kinase (AMPK) is a good candidate to explain these effects. Recent work using a muscle-specific knockout of the upstream kinase, LKB1, has confirmed that the LKB1-->AMPK cascade is the signaling pathway responsible for many of these effects.
摘要
收缩会引起肌肉中显著的代谢变化，而AMP激活的蛋白激酶（AMPK）是解释这些效应的一个很好的候选分子。最近利用肌肉特异性敲除上游激酶LKB1的研究工作证实，LKB1→AMPK级联反应是负责许多此类效应的信号通路。
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