2型糖尿病胰岛素分泌的分子缺陷 - Suppr

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超能文献

Molecular defects in insulin secretion in type-2 diabetes.

作者信息

Ashcroft Frances M, Rorsman Patrik

机构信息

University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, England.

出版信息

Rev Endocr Metab Disord. 2004 May;5(2):135-42. doi: 10.1023/B:REMD.0000021435.87776.a7.

DOI:10.1023/B:REMD.0000021435.87776.a7

PMID:15041789

Abstract

摘要

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Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?Kir6.2基因多态性使β细胞ATP敏感性钾通道对酰基辅酶A的激活敏感：这是2型糖尿病易感性增加的一种可能细胞机制吗？

Diabetes. 2003 Oct;52(10):2630-5. doi: 10.2337/diabetes.52.10.2630.

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