Graf N, Semler O, Reinhard H
Abteilung für Pädiatrische Hämatologie und Onkologie, Universitätsklinik für Kinder- und Jugendmedizin, Homburg.
Urologe A. 2004 Apr;43(4):421-8. doi: 10.1007/s00120-004-0551-4.
Wilms' tumor is the most common malignant renal tumor in children. Dramatic improvements in survival have occurred as the result of advances in anesthetic and surgical management, irradiation, and chemotherapy. Today treatments are based on several multicenter trials and studies conducted by the SIOP in Europe and NWTS in the USA. The main objectives of these trials and studies are to treat patients according to well-defined risk groups in order to achieve the highest cure rates, to decrease the frequency and intensity of acute and late toxicity, and to minimize the cost of therapy. The SIOP trials and studies largely focus on the issue of preoperative therapy whereas patients treated according to NWTS are primarily operated.
肾母细胞瘤是儿童最常见的恶性肾肿瘤。由于麻醉和外科管理、放疗及化疗方面的进展，生存率有了显著提高。如今的治疗基于欧洲国际小儿肿瘤学会（SIOP）和美国国立威尔姆斯瘤研究组（NWTS）开展的多项多中心试验和研究。这些试验和研究的主要目标是根据明确界定的风险组对患者进行治疗，以实现最高的治愈率，降低急慢性毒性的发生频率和严重程度，并使治疗成本降至最低。SIOP的试验和研究主要关注术前治疗问题，而按照NWTS方案治疗的患者则主要接受手术。
