Sinclair A, Johnston E, Badran D H, Neilson M, Soutar D S, Robertson A G, McDonald S W
Laboratory of Human Anatomy, University of Glasgow, Glasgow, Scotland, UK.
Clin Anat. 2004 Apr;17(3):227-32. doi: 10.1002/ca.10180.
We reported previously that skin flaps transplanted to the oral cavity in reconstructive surgery for oral cancer frequently acquired the gross appearance of buccal mucosa. The changes were shown to be reactive in nature. The "changed" flaps generally had a heavier infiltration of leukocytes in the dermis and appeared to have thicker epithelium. The present study quantifies these parameters, as well as the numbers of intraepithelial leukocytes. The flaps that had acquired the gross appearance of oral mucosa had significantly thicker epithelium, larger numbers of dermal leukocytes, and more intraepidermal inflammatory cells per unit length than flaps that retained the gross appearance of thin skin. No correlation was found between these changes and radiotherapy.
我们之前报道过，在口腔癌重建手术中移植到口腔的皮瓣常常呈现出颊黏膜的大体外观。结果表明这些变化本质上是反应性的。“发生变化”的皮瓣通常在真皮层有更密集的白细胞浸润，并且上皮似乎更厚。本研究对这些参数以及上皮内白细胞的数量进行了量化。呈现出口腔黏膜大体外观的皮瓣，与保留薄皮肤大体外观的皮瓣相比，其上皮显著更厚，真皮白细胞数量更多，每单位长度的表皮内炎性细胞也更多。未发现这些变化与放疗之间存在相关性。
