Badran D, Soutar D S, Robertson A G, Reid O, Milne E W, McDonald S W, Scothorne R J
Laboratory of Human Anatomy, University of Glasgow, United Kingdom.
Clin Anat. 1998;11(6):379-89. doi: 10.1002/(SICI)1098-2353(1998)11:6<379::AID-CA3>3.0.CO;2-H.
Radial forearm skin flaps transplanted into the oral cavity in patients undergoing treatment for intra-oral tumors frequently acquire a gross appearance resembling that of buccal mucosa. This article reports studies of biopsies of the flaps in 53 patients, of which 21 showed changes at some stage in the follow-up period. The project aims to determine whether 1) the change in the epithelium to a mucosal form is genuine or reactive, 2) a creeping replacement of epidermis results from the surrounding buccal epithelium, 3) alterations in the epidermis could be associated with changes in the dermis, 4) the change is caused by radiotherapy. Examination of the biopsies by resin histology and transmission electron microscopy shows that the changes may be reversible: it suggests that they are reactive in nature, and related to the degree of dermal inflammation, rather than to the effect of radiotherapy. The dermis persists as such and is not replaced by buccal lamina propria.
在接受口腔肿瘤治疗的患者中，将桡侧前臂皮瓣移植到口腔内后，皮瓣的外观通常会变得与颊黏膜相似。本文报告了对53例患者皮瓣活检的研究，其中21例在随访期间的某个阶段出现了变化。该项目旨在确定：1）上皮向黏膜形式的变化是真实的还是反应性的；2）表皮的渐进性替代是否源于周围的颊上皮；3）表皮的改变是否与真皮的变化有关；4）这种变化是否由放疗引起。通过树脂组织学和透射电子显微镜对活检组织进行检查表明，这些变化可能是可逆的：这表明它们本质上是反应性的，与真皮炎症程度有关，而非放疗的影响。真皮保持原样，不会被颊固有层替代。
