Greenfield Ronald A, Bronze Michael S
Department of Medicine, Section of Infectious Diseases, University of Oklahoma Health Sciences Center, 920 Stanton Young Blvd, Oklahoma City, OK 73190, USA.
Curr Opin Investig Drugs. 2004 Feb;5(2):135-40.
An important part of biodefense is the optimization of current therapy and the development of new therapeutic options for the treatment of the diseases most likely encountered in the form of biological weapons. Guidelines for the prevention and treatment of anthrax, plague, tularemia and botulinum toxin intoxication are reviewed. The strategies in development for the prevention of anthrax focus primarily on active and passive immunization against protective antigen, because of its central role as a toxin delivery module. Novel vaccine strategies for plague, tularemia and botulism are also reviewed.
生物防御的一个重要部分是优化当前的治疗方法，并开发新的治疗方案，以治疗最有可能以生物武器形式出现的疾病。本文回顾了炭疽、鼠疫、兔热病和肉毒杆菌毒素中毒的预防和治疗指南。由于保护性抗原作为毒素传递模块的核心作用，目前正在开发的预防炭疽的策略主要集中在针对保护性抗原的主动和被动免疫。本文还回顾了针对鼠疫、兔热病和肉毒中毒的新型疫苗策略。
