Bramwell Vincent W, Eyles Jim E, Oya Alpar H
School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Adv Drug Deliv Rev. 2005 Jun 17;57(9):1247-65. doi: 10.1016/j.addr.2005.01.010. Epub 2005 Apr 18.
Expanding identification of potentially protective subunit antigens and correlates of protection has provided a basis for the introduction of safer vaccines. Despite encouraging results in animal models, the significant potential of particulate delivery systems in vaccine design has not yet translated into effective vaccines available for use in humans. This review article will focus on the current status of the development of particulate vaccines, mainly liposomes and bio-degradable polymers, against potential agents for biowarfare: plague, anthrax, botulinum, and smallpox; and filoviruses: Marburg and Ebola.
对潜在保护性亚单位抗原的不断深入识别以及保护相关性研究为引入更安全的疫苗奠定了基础。尽管在动物模型中取得了令人鼓舞的结果，但颗粒递送系统在疫苗设计中的巨大潜力尚未转化为可用于人类的有效疫苗。这篇综述文章将聚焦颗粒疫苗（主要是脂质体和可生物降解聚合物）针对生物战潜在病原体（鼠疫、炭疽、肉毒杆菌和天花）以及丝状病毒（马尔堡病毒和埃博拉病毒）的研发现状。
