Bocian-Sobkowska J, Malendowicz L K, Woźniak W
Department of Anatomy, University School of Medical Sciences, Poznań, Poland.
Histol Histopathol. 1992 Jul;7(3):415-20.
Histological and morphometric studies were performed on 30 thyroid glands obtained from normal human fetuses. Their crown-rump length (CRL) ranged from 57 to 190 mm, corresponding to the gestational age of 10-20 weeks. The weight of the thyroid gland increased proportionally in relation to CRL, foot length and fetus weight. The first follicles containing PAS-positive colloid were observed in the peripheral part of the thyroid gland of 57 mm CRL fetus. The number of follicles per 1 mm2 of thyroid surface section increased up to 85 mm CRL and thereafter gradually declined for the end of studied period of fetal life. The volumes (in mm3) of thyroid epithelium, colloid and stroma, beginning from 85 mm increased proportionally to the CRL while the height of epithelial cells did not change. The epithelium/colloid ratio decreased notably to 165 mm CRL and thereafter remained constant. Results of the present study suggest that the thyroid gland of human fetus approaches structural maturity in 17.5 week of gestation.
对取自正常人类胎儿的30个甲状腺进行了组织学和形态计量学研究。它们的顶臀长（CRL）在57至190毫米之间，对应于10至20周的胎龄。甲状腺的重量与CRL、足长和胎儿体重成比例增加。在CRL为57毫米的胎儿甲状腺外周部分观察到了第一个含有PAS阳性胶体的滤泡。每平方毫米甲状腺表面切片的滤泡数量在CRL达到85毫米时增加，此后在胎儿生命研究期结束时逐渐下降。从85毫米开始，甲状腺上皮、胶体和基质的体积（立方毫米）与CRL成比例增加，而上皮细胞的高度没有变化。上皮/胶体比率在CRL为165毫米时显著下降，此后保持恒定。本研究结果表明，人类胎儿的甲状腺在妊娠17.5周时接近结构成熟。
