Bocian-Sobkowska J, Woźniak W, Malendowicz L K
Department of Anatomy, University School of Medical Sciences, Poznań, Poland.
Histol Histopathol. 1997 Jan;12(1):79-84.
Histological and morphometric studies were performed on 27 thyroid glands obtained from normal fetuses ranging between 23 to 40 weeks of intra-uterine life. In the thyroids the volume of gland, colloid, and stroma were calculated by means of differential pointcounting method and the height of the thyroid follicular cells was measured. Moreover, the epithelium/colloid ratio in the thyroid gland, a very sensitive parameter of stimulation of the glands by TSH, was calculated. Regarding the values of this ratio in human fetal thyroid gland, the intra-uterine development of the gland may be divided into three distinct stages. The first one, between weeks 10-18 is characterized by massive folliculogenesis and gradual accumulation of the colloid. The second stage, between weeks 19-29 of fetal life is characterized by rather unchanged values of epithelium/colloid ratio and the size of follicles. The third stage, after the 29th week of development is characterized by a gradual increase in the epithelium/colloid ratio and a decrease in the size of follicles.
对27个取自妊娠23至40周正常胎儿的甲状腺进行了组织学和形态计量学研究。在甲状腺中，通过微分点计数法计算腺体、胶体和基质的体积，并测量甲状腺滤泡细胞的高度。此外，还计算了甲状腺上皮/胶体比值，这是TSH刺激腺体的一个非常敏感的参数。关于人类胎儿甲状腺中该比值的值，腺体的子宫内发育可分为三个不同阶段。第一个阶段，在第10 - 18周之间，其特征是大量滤泡形成和胶体逐渐积累。第二个阶段，在胎儿期第19 - 29周之间，其特征是上皮/胶体比值和滤泡大小的值相当稳定。第三个阶段，在发育第29周之后，其特征是上皮/胶体比值逐渐增加，滤泡大小减小。
