Oladipo O O, Ajala M O, Okubadejo N, Danesi M A, Afonja O A
Department of Clinical Pathology, College of Medicine, Idi-Araba, Lagos, Nigeria.
Niger Postgrad Med J. 2003 Dec;10(4):234-7.
The objective of this study was to determine the relationship between plasma magnesium levels and epilepsy. The study was carried out at the Lagos University Teaching Hospital. Plasma magnesium was estimated using the calmigite dye colorimetric method in 45 adults with epilepsy and 35 healthy controls. Plasma concentrations of calcium, phosphorus and albumin were also estimated. The mean plasma magnesium in the patients was 0.98 mm0l/L (0.05) while that in the controls was 1.15 mmol/L (0.28). The mean plasma magnesium in the epileptics was significantly lower than that obtained in the controls (p < 0.001). Age of onset of seizures, seizure frequency and duration of treatment did not influence the plasma magnesium levels. Low plasma magnesium is associated with epilepsy, further studies may determine the influence of anti-epileptic drug therapy on plasma magnesium levels.
magnesium, seizures, Nigeria.
本研究的目的是确定血浆镁水平与癫痫之间的关系。该研究在拉各斯大学教学医院进行。采用钙镁试剂比色法对45例成年癫痫患者和35例健康对照者的血浆镁进行了测定。同时还测定了血浆钙、磷和白蛋白的浓度。患者的平均血浆镁为0.98 mmol/L（标准差0.05），而对照组为1.15 mmol/L（标准差0.28）。癫痫患者的平均血浆镁显著低于对照组（p < 0.001）。癫痫发作的起始年龄、发作频率和治疗持续时间均不影响血浆镁水平。低血浆镁与癫痫有关，进一步的研究可能会确定抗癫痫药物治疗对血浆镁水平的影响。
镁、癫痫发作、尼日利亚
