Peschke T, Schröer H P, Augsten K
Central Institute of Microbiology and Experimental Therapy, Jena, Germany.
Exp Toxicol Pathol. 1992 Jun;44(3):154-9. doi: 10.1016/S0940-2993(11)80153-3.
The s.c. injection of cis-DDP into ABD2F1 mice (8 mg/kg b.m.) resulted in alterations of size and surface structure of peritoneal macrophages (PM) and in a reduction of the mean number of Concanavalin A (ConA) binding sites of PM. The PM population of control mice which received physiological saline only consisted of 2 subgroups with a higher and a lower mean ConA binding site number per cell. Contrarily, PM of cis-DDP-treated mice failed the subpopulation with higher ConA binding site number. A loss of this subpopulation was also found in mice treated with platinum salt K2PtCl4 or K2PtCl6. X-ray microanalytically determined elemental contents of PM of control and treated mice showed a correlation between ConA binding site number and cellular concentration of phosphorus or sulphur with the exception of a small group of PM which was characterized by a high content of sulphur and a low number of ConA binding site. This correlation was not found in normal mice.
向ABD2F1小鼠皮下注射顺铂（8毫克/千克体重）会导致腹腔巨噬细胞（PM）的大小和表面结构发生改变，并使PM的刀豆球蛋白A（ConA）结合位点平均数量减少。仅接受生理盐水的对照小鼠的PM群体由两个亚组组成，每个细胞的ConA结合位点数量平均值较高和较低。相反，经顺铂处理的小鼠的PM没有ConA结合位点数量较高的亚群。在用铂盐K2PtCl4或K2PtCl6处理的小鼠中也发现了该亚群的缺失。X射线微量分析测定的对照小鼠和处理小鼠的PM元素含量表明，除了一小部分以高硫含量和低ConA结合位点数量为特征的PM外，ConA结合位点数量与细胞磷或硫浓度之间存在相关性。在正常小鼠中未发现这种相关性。
