Zacny J P, Lichtor J L, Zaragoza J G, de Wit H
Department of Anesthesia and Critical Care, University of Chicago, IL.
J Subst Abuse. 1992;4(2):197-207. doi: 10.1016/0899-3289(92)90019-t.
The effects of food deprivation on the subjective, psychomotor, and physiological responses to intravenous fentanyl (50 micrograms/70 kg) were studied in 6 healthy male volunteers. A randomized, placebo-controlled, crossover design was used in which subjects were injected with fentanyl or saline after either 2, 12, or 24 hours of fasting. Subjects completed several subjective effects questionnaires as well as psychomotor tasks prior to, and at regular intervals, following the intravenous injection for a 3-hour period. An observer-rated behavioral checklist was completed at regular intervals during the session and several physiological measures (including measurement of pupil size) were recorded. Fentanyl induced opiate-like mood changes, miosis (pupil constriction), and impairment of extraocular muscle control, and 4 of the 6 subjects reported liking the effects; however, fasting had no impact on any of fentanyl's effects. We conclude that food deprivation up to 24 hours does not alter the subjective, psychomotor, or physiological response to the opiate, fentanyl.
在6名健康男性志愿者中研究了食物剥夺对静脉注射芬太尼（50微克/70千克）的主观、精神运动和生理反应的影响。采用随机、安慰剂对照、交叉设计，让受试者在禁食2、12或24小时后注射芬太尼或生理盐水。受试者在静脉注射前及注射后的3小时内定期完成几份主观效应问卷以及精神运动任务。在实验过程中定期完成一份由观察者评定的行为清单，并记录几项生理指标（包括瞳孔大小测量）。芬太尼引起类阿片样情绪变化、瞳孔缩小（瞳孔收缩）和眼外肌控制受损，6名受试者中有4名报告喜欢这些效应；然而，禁食对芬太尼的任何效应均无影响。我们得出结论，长达24小时的食物剥夺不会改变对阿片类药物芬太尼的主观、精神运动或生理反应。
