Zacny J P, Lichtor J L, Binstock W, Coalson D W, Cutter T, Flemming D C, Glosten B
Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois 60637.
Psychopharmacology (Berl). 1993;111(3):306-14. doi: 10.1007/BF02244946.
Meperidine is a mu opiate agonist that is frequently used to treat pain. We examined in healthy volunteers (N = 10) the effects of intravenous meperidine (0, 0.25, 0.5, and 1.0 mg/kg) on mood and psychomotor performance. A randomized, placebo-controlled, crossover design was used in which subjects were injected with meperidine or saline in a double-blind fashion. Subjects completed several subjective effects questionnaires commonly used in abuse liability testing studies before drug injection and at periodic intervals for up to 5 h after drug injection. Subjects also completed several psychomotor tests. Meperidine produced a constellation of subjective effects in a dose-related fashion, including increases in ratings of "sedated," "coasting or spaced out" and "feel drug effect" ratings. Many of the drug's subjective effects persisted up to 4 or 5 h after administration of the 1.0 mg/kg dose. Drug liking ratings assessed on a visual analog scale were increased after meperidine injection in about half of the subjects (P = 0.09). Eye-hand coordination was affected slightly by meperidine but other indices of psychomotor functioning were unaffected. Miosis increased in a dose-related fashion. Other physiological parameters, such as vital signs, were not affected by meperidine. We conclude that meperidine in healthy volunteers has robust and long-lasting effects on mood, but may have weaker effects on psychomotor performance.
哌替啶是一种μ阿片受体激动剂，常用于治疗疼痛。我们在健康志愿者（N = 10）中研究了静脉注射哌替啶（0、0.25、0.5和1.0 mg/kg）对情绪和精神运动表现的影响。采用随机、安慰剂对照、交叉设计，受试者以双盲方式注射哌替啶或生理盐水。受试者在注射药物前以及注射药物后长达5小时的定期时间内，完成了滥用倾向测试研究中常用的几份主观效应问卷。受试者还完成了几项精神运动测试。哌替啶以剂量相关的方式产生一系列主观效应，包括“镇静”“放松或恍惚”和“感觉有药物作用”评分增加。在给予1.0 mg/kg剂量后，许多药物的主观效应持续长达4或5小时。在大约一半的受试者中，注射哌替啶后通过视觉模拟量表评估的药物喜好评分增加（P = 0.09）。哌替啶对眼手协调有轻微影响，但对其他精神运动功能指标没有影响。瞳孔缩小呈剂量相关增加。其他生理参数，如生命体征，不受哌替啶影响。我们得出结论，健康志愿者中的哌替啶对情绪有强烈且持久的影响，但对精神运动表现的影响可能较弱。
