Geris L, Andreykiv A, Van Oosterwyck H, Sloten J Vander, van Keulen F, Duyck J, Naert I
Division of Biomechanics and Engineering Design, Faculty of Engineering, Katholieke Univeriteit Leuven, Celestijnenlaan 200A, Leuven B-3000, Belgium.
J Biomech. 2004 May;37(5):763-9. doi: 10.1016/j.jbiomech.2003.09.026.
The application of a bone chamber provides a controlled environment for the study of tissue differentiation and bone adaptation. The influence of different mechanical and biological factors on the processes can be measured experimentally. The goal of the present work is to numerically model the process of peri-implant tissue differentiation inside a bone chamber, placed in a rabbit tibia. 2D and 3D models were created of the tissue inside the chamber. A number of loading conditions, corresponding to those applied in the rabbit experiments, were simulated. Fluid velocity and maximal distortional strain were considered as the stimuli that guide the differentiation process of mesenchymal cells into fibroblasts, chondrocytes and osteoblasts. Mesenchymal cells migrate through the chamber from the perforations in the chamber wall. This process is modelled by the diffusion equation. The predicted tissue phenotypes as well as the process of tissue ingrowth into the chamber show a qualitative agreement with the results of the rabbit experiments. Due to the limited number of animal experiments (four) and the observed inter-animal differences, no quantitative comparison could be made. These results however are a strong indication of the feasibility of the implemented theory to predict the mechano-regulation of the differentiation process inside the bone chamber.
骨腔的应用为组织分化和骨适应性研究提供了一个可控环境。不同机械和生物因素对这些过程的影响可以通过实验来测量。本研究的目的是对置于兔胫骨内的骨腔内种植体周围组织分化过程进行数值模拟。创建了骨腔内组织的二维和三维模型。模拟了一些与兔实验中应用的条件相对应的加载条件。流体速度和最大畸变应变被视为引导间充质细胞分化为成纤维细胞、软骨细胞和成骨细胞的刺激因素。间充质细胞从腔壁的穿孔处穿过骨腔。这个过程由扩散方程建模。预测的组织表型以及组织向腔内生长的过程与兔实验结果在定性上一致。由于动物实验数量有限（四只）以及观察到的动物间差异，无法进行定量比较。然而，这些结果有力地表明了所实施理论预测骨腔内分化过程机械调节的可行性。
