Duyck J, Vandamme K, Geris L, Van Oosterwyck H, De Cooman M, Vandersloten J, Puers R, Naert I
Department of Prosthetic Dentistry, BIOMAT Research Group, Catholic University of Leuven, Belgium.
Arch Oral Biol. 2006 Jan;51(1):1-9. doi: 10.1016/j.archoralbio.2005.04.003. Epub 2005 May 31.
The aim of this study was to evaluate the effect of various degrees of implant displacement on the tissue differentiation around immediately loaded cylindrical turned titanium implants.
The experiments were conducted in repeated sampling bone chambers placed in the tibia of 10 rabbits. Tissues could grow into the bone chambers via perforations. Due to its double structure, tissues inside the chamber could be harvested leaving the chamber intact. This allowed several experiments within the same animal. The chambers contained a cylindrical turned titanium implant that was loaded in a well-controlled manner. In each of the 10 chambers, four experiments were conducted with the following test conditions: immediate implant loading by inducing 0 (control), 30, 60 and 90 microm implant displacement, 800 cycles per day at a frequency of 1 Hz, twice a week during a period of 6 weeks. Histological and histomorphometrical analyses were performed on methylmethacrylate histological sections. An ANOVA was conducted on the dataset.
The total tissue volume was significantly lowest in the unloaded control condition. The bone volume fraction on the other hand, was significantly larger in the unloaded and 90 microm implant displacement, compared to the 30 microm implant displacement. Bone density increased with increasing micro-motion with significantly higher values for the 60 microm- and 90 microm-test conditions compared to the unloaded situation. The chance to have bone-to-implant contact decreased in case of micro-motion at the tissues-implant interface.
The magnitude of implant displacement had a statistically significant effect on the tissue differentiation around immediately loaded cylindrical turned titanium implants. Implant micro-motion had a detrimental effect on the bone-to-implant contact in an immediate loading regimen.
本研究旨在评估不同程度的种植体位移对即刻负重的圆柱形车削钛种植体周围组织分化的影响。
实验在置于10只兔子胫骨中的重复采样骨腔中进行。组织可通过穿孔长入骨腔。由于其双重结构，可在保持骨腔完整的情况下采集腔内组织。这使得能在同一动物体内进行多项实验。骨腔中包含一个以良好控制方式加载的圆柱形车削钛种植体。在10个骨腔中的每一个中，在以下测试条件下进行了四项实验：通过诱导0（对照）、30、60和90微米的种植体位移进行即刻种植体加载，每天以1赫兹的频率进行800次循环，在6周的时间内每周两次。对甲基丙烯酸甲酯组织切片进行组织学和组织形态计量学分析。对数据集进行方差分析。
在未加载的对照条件下，总组织体积显著最低。另一方面，与30微米种植体位移相比，在未加载和90微米种植体位移情况下，骨体积分数显著更大。骨密度随着微动增加而增加，与未加载情况相比，60微米和90微米测试条件下的值显著更高。在组织 - 种植体界面发生微动时，骨与种植体接触的机会减少。
种植体位移的大小对即刻负重的圆柱形车削钛种植体周围的组织分化具有统计学上的显著影响。在即刻加载方案中，种植体微动对骨与种植体的接触有不利影响。
