Matzner W, Chong P, Xu G, Ching W
Reproductive Immunology Associates, Los Angeles, CA 90064.
J Reprod Med. 1994 Jan;39(1):27-30.
Antiphospholipid antibodies are important in the etiology of recurrent pregnancy loss. To date, most studies have concentrated on antibodies to cardiolipin specifically. In this study, the serum of 352 women with recurrent pregnancy loss was studied by enzyme-linked immunosorbent assay for antibodies to six phospholipid epitopes: cardiolipin, phosphoserine, phosphoglycerol, phosphoethanolamine, phosphatidic acid and phosphoinositol. Of these women, 59.1% had either an IgG or IgM antibody to one of the six phospholipids. This compared to only 4.6% in the control group. Approximately 75% of the isotypes were IgM. The most common phospholipid epitope was phosphoserine. However, in patients with antibodies to only one phospholipid, phosphoethanolamine was the most common. These findings support recent evidence that antiphospholipid antibodies may interfere with the formation of syncytiotrophoblasts in the placenta. In addition, antiphospholipid antibodies occur more frequently in patients who suffer recurrent miscarriages than was previously thought.
抗磷脂抗体在复发性流产的病因学中具有重要作用。迄今为止，大多数研究都特别集中在针对心磷脂的抗体上。在本研究中，采用酶联免疫吸附测定法对352例复发性流产女性的血清进行了检测，以分析其针对六种磷脂表位的抗体，这六种磷脂表位分别为：心磷脂、磷酸丝氨酸、磷酸甘油、磷酸乙醇胺、磷脂酸和磷酸肌醇。在这些女性中，59.1%的人针对六种磷脂中的一种产生了IgG或IgM抗体。相比之下，对照组中这一比例仅为4.6%。大约75%的同种型为IgM。最常见的磷脂表位是磷酸丝氨酸。然而，在仅针对一种磷脂产生抗体的患者中，磷酸乙醇胺是最常见的。这些发现支持了最近的证据，即抗磷脂抗体可能会干扰胎盘合体滋养层细胞的形成。此外，抗磷脂抗体在复发性流产患者中的出现频率比之前认为的更高。
