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Antimicrob Agents Chemother. 2004 Apr;48(4):1357-60. doi: 10.1128/AAC.48.4.1357-1360.2004.
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本文引用的文献

1
Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically.黄酮显著影响临床分离的耐甲氧西林金黄色葡萄球菌菌株中β-内酰胺耐药性的表型表达。
Biol Pharm Bull. 2003 Oct;26(10):1478-83. doi: 10.1248/bpb.26.1478.
2
Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus.细胞壁增厚是金黄色葡萄球菌对万古霉素耐药的一个常见特征。
J Clin Microbiol. 2003 Jan;41(1):5-14. doi: 10.1128/JCM.41.1.5-14.2003.
3
In vitro activity of 21 antimicrobials against vancomycin-resistant Staphylococcus aureus (VRSA) and heteroVRSA (hVRSA).
J Antimicrob Chemother. 2002 Nov;50(5):760-1. doi: 10.1093/jac/dkf184.
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Flavonoids: a review of probable mechanisms of action and potential applications.黄酮类化合物：作用机制及潜在应用的综述
Am J Clin Nutr. 2001 Oct;74(4):418-25. doi: 10.1093/ajcn/74.4.418.
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Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships.
J Med Chem. 2001 Jan 18;44(2):261-8. doi: 10.1021/jm0004190.
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Molecular properties of bacterial multidrug transporters.细菌多药转运蛋白的分子特性
Microbiol Mol Biol Rev. 2000 Dec;64(4):672-93. doi: 10.1128/MMBR.64.4.672-693.2000.
7
Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus.从半枝莲中分离出的植物化学黄酮及其对耐甲氧西林金黄色葡萄球菌的抗菌活性。
J Ethnopharmacol. 2000 Oct;72(3):483-8. doi: 10.1016/s0378-8741(00)00265-8.
8
Staphylococcal cell wall: morphogenesis and fatal variations in the presence of penicillin.葡萄球菌细胞壁：青霉素存在下的形态发生与致命变异
Microbiol Mol Biol Rev. 1998 Dec;62(4):1371-414. doi: 10.1128/MMBR.62.4.1371-1414.1998.
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The challenge of antibiotic resistance.抗生素耐药性的挑战。
Sci Am. 1998 Mar;278(3):46-53. doi: 10.1038/scientificamerican0398-46.
10
Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin.耐万古霉素异质性金黄色葡萄球菌菌株在日本医院的传播。
Lancet. 1997 Dec 6;350(9092):1670-3. doi: 10.1016/S0140-6736(97)07324-8.

6,7-二羟基黄酮显著增强耐甲氧西林或甲氧西林敏感金黄色葡萄球菌对β-内酰胺类药物的敏感性。

6,7-dihydroxyflavone dramatically intensifies the susceptibility of methicillin-resistant or -sensitive Staphylococcus aureus to beta-lactams.

作者信息

Sato Youichi, Shibata Hirofumi, Arakaki Naokatu, Higuti Tomihiko

机构信息

Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan.

出版信息

Antimicrob Agents Chemother. 2004 Apr;48(4):1357-60. doi: 10.1128/AAC.48.4.1357-1360.2004.

DOI:10.1128/AAC.48.4.1357-1360.2004
PMID:15047543
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC375321/
Abstract

We have demonstrated that 6,7-dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA) but that at concentrations less than MIC it synergistically elevates the susceptibility of clinically isolated MRSA and methicillin-sensitive S. aureus strains to beta-lactam antibiotics from 8- to 32,800-fold.

摘要

我们已经证明，6,7-二羟基黄酮本身对耐甲氧西林金黄色葡萄球菌（MRSA）只有微弱的抗菌作用，但在浓度低于最低抑菌浓度（MIC）时，它能协同提高临床分离的MRSA和甲氧西林敏感金黄色葡萄球菌菌株对β-内酰胺类抗生素的敏感性，提高倍数为8至32,800倍。